Along with disorders of protein metabolism in animals of both groups appeared and gradually grew syndrome, traditionally described as a syndrome of endogenous intoxication (EI). By the end of the first day experiment, all dogs became inhibited, did not respond to the call and offered food. Animals in both groups lost the ability to self-movement, decreased pain sensitivity. Breathing was rapid, superficial ripple on the peripheral vessels is weak, there is a pronounced tachycardia, cyanosis, and dry mucous membranes, Auscultation noted the absence of peristaltic bowel noises. These changes showed a dramatic impairment of the function of vital organs and systems. At relaparotomy in the early 2 days in 100% of the loops of bowel distension were determined, fibrinous plaque on the parietal and visceral peritoneum, large amount of purulent exudate, with a marked hemorrhagic kolibatsillyarnym smell.
The development of pathological process in the control group of animals was accompanied by further deepening proteinase inhibitor imbalance, and disorders of protein metabolism. Thus, TPA of the plasma to the 3rd day of the experiment was growing and exceeded the initial values of 5 (Fig. 1), at the same time, the inhibitory potential of the blood continued to decline: level of alpha-1-PI at this time amounted to 42.4% from baseline values (Fig. 2). sharp increase in the proteolytic capacity of the blood, indicating that endogenous proteolysis of generalization, leads to a significant reduction levels of total protein and albumin of 1.2 and 1.3 times from baseline, respectively. Following initial medical treatment, all animals in the control group continued to steadily phenomenon of endotoxemia deepen. At phenomena of gross disturbances of vital functions within 36-72 hours from the start of the experiment all pronounced dead animals in the control group. The average life expectancy of the experimental animals of this group was 49.0 9.0 hours from the start of the experiment. At autopsy in the abdominal cavity – evidence fibrinopurulent inflammation, enlarged liver full-blooded, multiple subserous petechial hemorrhages in all departments small intestine, fibrin gluing some of its loops.